Researchers from Institute of Science, Tokyo, have developed a light-sensitive probe that crosslinks with 5-formylcytosine (5fC), a key epigenetic intermediate, enabling its detection in target DNA.

Targeted next-generation sequencing (NGS) is often performed using hybridization-based target enrichment, which deploys oligonucleotide probes to capture regions of interest for downstream sequencing.

In releasing its DualChip microarray system, Eppendorf http://www.eppendorf.com of Hamburg, Germany, has blurred the lines between cDNA and oligonucleotide probes ...

About nonradioactive nucleic acid detection -- Isolation of DNA from plants -- Isolation of high-molecular-weight DNA from animal cells -- Restriction enzyme digestion, gel electrophoresis and vacuum ...

Synthetic oligonucleotides have been used as critical research reagents in the biotechnology industry since its beginning in the 1970s. Their increasing use first led to the formation of many core ...

High-resolution melting has proven to be a highly sensitive method for mutation discovery. PCR is performed in the presence of the double-strand DNA binding dye LCGreen® Plus. Samples are then ...

PCR has fundamentally changed molecular biology, offering a rapid means to amplify minute quantities of DNA. Real-time quantitative PCR (Q-PCR) techniques are designed to facilitate accurate ...