In addition, the hydrophobic nature that makes a lipid a good barrier component also makes it tricky to image with expansion microscopy. "The tagging methods used for this type of microscopy don't ...

Researchers are redesigning lipid nanoparticles to do more than shuttle mRNA into cells, with preclinical studies suggesting engineered particles can influence immune metabolism in ways that may ...

Penn Engineers have discovered a novel means of directing lipid nanoparticles (LNPs), the revolutionary molecules that delivered the COVID-19 vaccines, to target specific tissues, presaging a new era ...

Postdoctoral fellow and co-first author Dongyoon Kim demonstrates some of the equipment used to craft the new ionizable lipids. [Bella Ciervo, Penn Engineering] The explosion of mRNA vaccines brought ...

Spanning the Gap between Synthetic Lipid Chemisty and Signal Transduction Biology Many scientists are familiar with lipids as hydrophobic molecules that form biological cell membranes. However, ...

Nanoparticle coatings can come loose in the body, causing therapies to miss their target or trigger side effects. The development and subsequent approval of SARS-CoV-2 mRNA vaccines saved countless ...

For centuries arsenic has been synonymous with poison and peril. However, it is also ubiquitous in the Earth’s crust, and runoff from natural deposits and industrial processes has spread it throughout ...

(Nanowerk News) Penn Engineers have discovered a novel means of directing lipid nanoparticles (LNPs), the revolutionary molecules that delivered the COVID-19 vaccines, to target specific tissues, ...