From 2001 to 2011, the US Food and Drug Administration approved 9 single-enantiomer drugs with racemic precursors. None showed pre-approval evidence of improved efficacy over the racemic precursor. We ...

In chemistry, breaking a mirror isn’t always a harbinger of bad luck. Using a trio of catalysts and some blue light, researchers have transformed a racemic mixture of mirror-image molecules into a ...

There is considerable interest in skewing the transmission of chirality, or ‘handedness’, from the molecular to the supramolecular level so that single-handed superstructures are created from mixed ...

It was the Softenon disaster that made the pharmaceutical industry fully aware of the importance of knowing the enantiomeric purity and chirality of drugs and their metabolites. This disaster involved ...

Homochirality is a fundamental feature of all living organism. It is well known that a pair of enantiomers of chiral drug molecules, whose structures have a non-superimposable mirror-image ...

Microwave spectroscopy overcomes some of the limitations of circular dichroism and vibrational circular dichroism in analyzing enantiomers. Chirality plays an important role in pharmaceutical ...

Chiral resolution remains a critical challenge in pharmaceutical development, where the demand for enantiopure compounds continues to shape both strategy and innovation. This article explores how ...

Developments involve stereoretentive cross-coupling, enantioselective alcohol silylation, strategies for amplifying signals in circular dichroism spectroscopy, and a synthetic route for the natural ...

A mixture of a both enantiomers of carvone and both enantiomers of an orange ferrocene probe can be loaded into this device. Each enantiomer comes out the other end of the device as a separate ...