Leukotriene modifiers (leukotriene antagonists) are medicines used to manage allergic rhinitis or allergies, as well as prevent asthma. These novel drugs work by blocking the action of leukotrienes.

Inflammation and its timely resolution represent a vital physiologic response to infection, injury, and “sterile provocation” by endogenous stimuli. There is a growing appreciation that the initiation ...

*For decades, asthma treatment has focused on molecules called leukotrienes. These compounds cause inflammation, tighten airways, and make breathing harder. Drugs like Singulair were created to block ...

Leukotriene modifiers can help control asthma symptoms by reducing inflammation and airway constriction. These medications alter the activity of leukotrienes, which drive inflammation and play a role ...

Three G protein–coupled receptors, the cysteinyl leukotriene receptors 1, 2, and 3 (CysLTR1, CysLTR2, and CysLTR3), mediate the effects of the cysteinyl leukotrienes in vivo. (Each receptor has a ...

In the study, "Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens," published in Science, researchers combined bulk and single‑cell RNA sequencing, in ...

Scleroderma interstitial lung disease (SLD) is a leading cause of morbidity and mortality in patients with systemic sclerosis. Although the pathogenesis of SLD is not clear, excessive fibrosis and ...

The mechanisms responsible for the formation of arterial aneurysms remain mysterious. Key features include extensive inflammation of the adventitia, the outermost layer of arteries, and dilation of ...

Allergies occur when the immune system treats a harmless foreign protein as an invader. The immune system mounts a full-scale response to the protein. This response involves releasing inflammatory ...